Innovations

Gemstone Bio’s Technology

Gemstone Bio utilizes exclusively-licensed core technology that was developed at Johns Hopkins University. The IP portfolio comprises a unique mix of innovative products and techniques. Our technology boasts a wide-range of regenerative medicine applications, including wound healing scaffolds and topical therapeutics.

Scaffold Technology

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Polymer-based scaffolds are extensively used in regenerative medicine applications because they provide a three-dimensional structure that simulates the native cell environment and extracellular matrix. Gemstone's first generation product is a novel biosynthetic scaffold for wound healing. Gemstone's scaffolds highly tunable, meaning they can easily be tailored for specific wound healing applications. The incorporation of active ingredients, including therapeutics, cells and growth factors, allow for continuous scaffold evolution.

Topical Therapeutic

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Researchers at Johns Hopkins have discovered that a well-known category of medications have a profoundly positive impact on the healing of chronic wounds via several specific biological mechanisms. This research is based on prior evidence that certain receptors are markedly increased in the wounds of older and diabetic patients. Increased levels of this pro-inflammatory receptor play a critical role in skin vulnerability, poor wound healing and the development of chronic wounds.

Published Papers

Gemstone Bio's technology is published in a variety of high-impact journals. Our science is subjected to rigorous peer-review to ensure scientific integrity and verifiable results.

Blood vessels made with less ado

“These developments, published in the Proceedings of the National Academy of Sciences, could bring life-supporting vessels a step closer to clinical use in treating wounds, diabetes, stroke, and heart disease.” The Baltimore Sun, October 4, 2013

5
Aug '16

Engineered Biopolymeric Scaffolds for Chronic Wound Healing

This mini-review provides a brief overview of chronic wound healing and current skin substitute treatment strategies while focusing on recent engineering approaches that regenerate skin using synthetic, biopolymeric scaffolds.

http://journal.frontiersin.org/article/10.3389/fphys.2016.00341/full

22
Jul '15

Journal of Investigative Dermatology | Acellular hydrogels for regenerative burn wound healing: translation from a porcine model

New study results show 3rd degree wounds treated with our product achieved complete re-epithelialization and nerve ingrowth. The regenerated skin demonstrated characteristics of uninjured skin. This affirms the superior wound healing performance of our biosynthetic scaffold technology.

http://www.nature.com/jid/journal/v135/n10/full/jid2015182a.html

14
Jun '13

Proceedings of the National Academy of Science of the United States of America | Self-organized vascular network from human pluripotent stem cells in a synthetic matrix

A bicellular vascular population, capable of maturing into ECs and pericytes, was derived from human pluripotent stem cells (hPSCs). These EVCs were able to self-organize and form microvascular networks in an engineered matrix, which survives implantation, integrates with the host vasculature, and establishes blood flow.

http://www.pnas.org/content/110/31/12601.abstract

27
Dec '11

Proceedings of the National Academy of Sciences of the United States of America | Scaffolds enhance angiogenic responses and promote complete skin regeneration during burn wound healing

A biosynthetic scaffold containing no additional growth factors, cytokines, or cells was developed that promotes neovascularization and skin regeneration in third-degree burn wounds in mice. Dermal regeneration with complete skin appendages was observed after 3 weeks. After 5 weeks, new hair growth and normal epidermal morphology and thickness were observed.

http://www.pnas.org/content/108/52/20976.abstract

21
Jul '11

Blood | Controlled activation of morphogenesis to generate a functional human microvasculature in a synthetic matrix

Synthetic, tunable hyaluronic acid (HA) hydrogels were developed that enabled human endothelial colony-forming cells (ECFCs) to form efficient vascular networks in vivo. HA hydrogels containing ECFCs anastomosed with the host’s circulation and supported blood flow in the hydrogel after transplantation. regeneration.

http://www.bloodjournal.org/content/118/3/804