Research

We are committed to developing wound care technologies from lab to bedside with a keen focus on clinically relevant products with superior patient outcomes.  We continue to optimize and improve our current technologies, building on the pre-clinical research and development at Johns Hopkins and at Gemstone.  We look to partner with leading academic and commercial institution to ensure high efficacy and consistency for our initial product offerings.

Pre-FDA Scaffold Development

Pre-FDA Scaffold Development

We are in the process of conducting FDA enabling studies on the scaffold.

Pre-IND Topical Development

Pre-IND Topical Development

We are currently involved in pre-clinical efficacy and topical formulation studies for a FDA IND submission.

Future Development

Future Development

We are exploring the possibility of using our products for other currently under-served markets, e.g. scaffold for hair restoration applications.

Associated Publications

Strategic Partnerships

Licensed Patents

Platform Technologies

Topical reformulation of valsartan for treatment of chronic wounds

Peter Abadir, Jeremy Walston, et. al.

Journal of Investigative Dermatology

Application of a re-purposed topical therapeutic to murine and porcine wounds significantly accelerated closure time and increased tensile strength compared to untreated wounds.  Additionally, the treated wounds exhibited higher mitochondrial activity, collagen deposition, and up-regulation of key pro-healing co-factors.

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Engineered biopolymeric scaffolds for chronic wound healing

Laura E. Dickinson and Sharon Gerecht

Frontiers in Physiology 

This review provides a brief overview of chronic wound healing and current skin substitute strategies while focusing on recent engineering approaches that regenerate skin using synthetic, biopolymeric scaffolds.

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Acellular hydrogel for regenerative burn wound healing: translation from a porcine model

Yu-I Shen, Hyun-Ho Greco Song, Sharon Gerecht, et. al. 

Journal of Investigative Dermatology

This paper outlines the development of a porcine model to third-degree burn wound healing.  The study showed that scaffold treated wounds accelerated wound healing closure rates, improved reepithelialization, and enhanced ECM remodeling compared to an untreated control in the developed burn model.  The scaffold also increased neovascularization and reinnervation within the wound site.

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Dextran hydrogel scaffolds enhance angiogenic responses and promote complete skin regeneration during burn wound healing

Guoming Sun, Sharon Gerecht, et. al. 

Proceedings of the National Academy of Sciences 

Seminal paper on using the dextran scaffold for advanced wound healing.  The scaffold promoted dermal regeneration with complete skin appendages compared to untreated wounds in a murine model.  The scaffold facilitated early inflammatory cell infiltration, neovascularization by day 7, and a mature epithelial structure with hair follicles and sebaceous glands by day 21.

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